Clinical Study Olive Tree Extract: Anti Cancer Effect

Abstract : 

The aim of the current study was to evaluate the anticancerous potential of a phenolic olive tree extract through his cytotoxic, antioxidant and antiangiogenic activities. The in vitro cytotoxic activity of a crude olive tree extract and his major constitutive components has been evaluated against human KB, HL60 cancer cell lines using MTS and flow cytometry. ROS production was estimated with the DCFHDA assay. Antiangiogenic activity was evaluated in vitro on endothelial cells tube formation and the pro-angiogenic factor expression was quantified using qRT-PCR. In vitro cellular assays have demonstrated the cytotoxic effect of the crude olive tree extract. This extract reduces significantly (p<0.05) ROS produced in cells exposed to oxidative stress. Beside this, olive tree extract has demonstrated a strong antiangiogenic activity, which was correlated with a significant decrease (p<0.05) in VEGF, angiopoietin and HIF1α expression. Basically, the evaluation of antiproliferative, antioxidant and anti-angiogenic activities could be the first step to formulate an efficient pharmaceutical product with preventive and/or curative properties against cancer.